Myocardial Ischemic Memory Imaging With Molecular Echocardiography

Myocardial ischemic memory imaging with molecular echocardiography.

BACKGROUND Diagnosing acute coronary syndrome in patients presenting with chest discomfort is a challenge. Because acute myocardial ischemia/reperfusion is associated with endothelial upregulation of leukocyte adhesion molecules, which persist even after ischemia has resolved, we hypothesized that microbubbles designed to adhere to endothelial selectins would permit echocardiographic identifica...

Detection of recent myocardial ischaemia by molecular imaging of P-selectin with targeted contrast echocardiography.

AIMS We hypothesized that molecular imaging of endothelial P-selectin expression with targeted myocardial contrast echocardiography (MCE) could identify recently ischaemic myocardium without infarction. METHODS AND RESULTS The microvascular behaviour of P-selectin-targeted (MB(p)) and control (MB(c)) microbubbles was assessed by intravital microscopy of the cremaster muscle in mice. Targeted ...

exercise stress echocardiography and tissue synchronization imaging of myocardial dyssynchrony

conclusions the tsi analysis in patients with cad may be considered an interesting parameter in addition to the conventional echocardiographic parameters during ese. background stress echocardiography represents one of the best possible imaging choice for the diagnosis and stratification of patients with coronary artery disease (cad). however, this imaging technique presents some limitations su...

myocardial strain and strain rate imaging: comparison between doppler derived strain imaging and speckle tracking echocardiography

Myocardial perfusion imaging: contrast echocardiography today and tomorrow.

The clinical need to evaluate myocardial perfusion is not satisfied by conventional imaging techniques (I). Angiography is frequently used to provide qualitative anatomic data, but it lacks a physiologic basis for assessing regional blood flow and is an unreliable predictor of it (2,3). Recent technical advances in contrast echocardiography permit direct perfusion assessment and promise to prov...